For more than a century, America’s universities and charitable foundations have been at the forefront of innovations that increased quality of life and extended longevity. Today more than ever, the nonprofit sector plays a crucial role in improving public health in the nation and around the world. But philanthropies, universities, and public charities vary greatly in their cultures, views, and capacity to effect meaningful change. So how can these disparate organizations coordinate their efforts for the greater good? That’s the art of alignment. We’ll examine how the most successful philanthropies and universities find common ground to change the world.